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Magnetic Force Imaging as a bio-imaging method for detection of single proteins
Friday, 9 May 2008, 16.00, W2.19 Magnetic nanoparticles become more and more popular object for biological and medical applications: drug delivery, hyperthermia, separation of cells, DNA and proteins, etc. We present biological application of a method based on force gradient detection of magnetic nanoparticles known as Magnetic Force Imaging (MFI). Behaviour of endothelin protein which was marked by 50 nm magnetic beads was studied in plasma membrane of cultured vascular smooth muscular cells. MFI allowed us to observe distribution of magnetic markers on the level of single protein. Magnetic imaging approach used in the research can be applied to other biological objects in order to trace them in fixed or live cells. The method development is interesting not only for biology, but gives a wide field for applications in physics. |
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